So if my application has a form and the user clicks on close instead of submit, I would like for the guide to end then. Is that possible?

Yes, it is most certainly possible.
Like many things, this is divided into 3 parts :)
1. On the step where you are expecting the user to click submit. Read more about how to Add another tooltip.
2. Create an invisible tip that would advance when the user clicks on the cancel button. 
see how here -
3. Add a branch to this new tip that would close the guide. The branch is activated as soon as the tip is 'complete' which on our case would be when the user clicks on the cancel button.
Inline image 1
You can read a detailed description about branches here -


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